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Capsaicin Clinical Studies
Oxford Medical Journal.
Repeated intranasal capsaicin applications to treat chronic migraine.
B. M. Fusco, G. Barzoi and F. Agrò. Rome, Italy.
Medline – Clinical
Trial
Capsaicin is effective Natural Allergy Remedy for psoriasis,
pruritus, and cluster headaches.
Department of Anesthesia and
Critical Care, the University of Chicago, Illinois
Intranasal Capsaicin Reduces Allergic Symptoms
Patients who were challenged with natural capsaicin
reported a long lasting relief of symptoms that included rhinnorhea, congestion,
sneezing and coughing (this relief was reported to have lasted up to 9 months
after treatment).
Johns Hopkins Bayview Medical
Center
Medline – Clinical
Trial
It has been suggested that treatment
of cluster headache (CH) patients with topical capsaicin may desensitize sensory
neurons by depleting the nerve terminals of substance P. We attempted to
determine whether capsaicin is effective in aborting CH attacks. Patients in
acute cluster were randomized to receive either capsaicin or placebo in the
ipsilateral nostril for 7 days. Patients recorded the severity of each headache
for 15 days. Headaches on days 8-15 of the study were significantly less severe
in the capsaicin group vs the placebo group. There was also a significant
decrease in headache severity in the capsaicin group on days 8-15 compared to
days 1-7, but not in the placebo group. Episodic CH patients appeared to benefit
more than chronic CH patients. These results indicate that intranasal capsaicin
may provide a new therapeutic option for the treatment of this
disease.
Clinical Immunology Unit, Massachusetts General Hospital,
Boston 92114.
Medline – Clinical
Trial
Intranasal medications for the treatment of headaches is
significantly more effective than by digestive means.Columbia University
College of Physicians & Surgeons, New York, NY,
Medline – Clinical
Trail
Intranasal Civamide (capsaicin) solution at a dose of 50
microg may be modestly effective in the preventive treatment of episodic cluster
headache.
Michigan Headache Pain and Neurological
Institute
Medline – Clinical
Trail
Based upon the results of this study, intranasal civamide may
be effective in the acute treatment of migraine headache.Diamond
Headache Clinic, Chicago, IL
Medline – Clinical
Trial
Finally, repeated applications of the drug to the nasal mucosa
result in the prevention of cluster headache attacks. On the basis of this
evidence, capsaicin appears to be a promising prototype for obtaining selective
analgesia in localised pain syndromes.
Department of Clinical
Medicine, University La Sapienza, Rome, Italy
Medline – Clinical
Trial
The number of spontaneously occurring migraine attacks was
significantly reduced in the 60 days after the end of natural capsaicin
treatment.
Institute of Internal Medicine and Clinical Pharmacology,
University of Florence, Italy
Medscape
A 2002
report in the Archives of Neurology reported the use of natual capsaicin nasal
spray to treat cluster and migraine headaches.[11] Capsaicin depletes substance
P and may represent a new treatment for this painful
condition.
Robert Baldor, MD University of Massachusetts Medical
School
The Wall Street Journal – Pepper
Unclogs Sinuses
“Since capsaicin desensitizes the mucous membranes
in the nose, it make them less irritated by airborne particles helping to
relieve congestion. We pepper our patients regularly using a solution of saline,
ethanol and capsaicin.”
J.S. LaCroix – Research Scientist University
Hospital, Geneva
